You will be provided with the deep foundations of core knowledge, practical skills and competence in data handling that will be required for the more specialised subsequent years and your future career. This mirrors year 1 of our medical biochemistry programme.
You will learn about the structures and reactions of molecules essential for life (amino-acids, proteins, nucleic acids, carbohydrates and lipids) and fundamental chemistry including thermodynamics, bio-inorganic chemistry and acids, bases and buffers. You will also learn about the experimental, analytical and computational methods used by our academics to investigate life in molecular detail. This includes recombinant DNA techniques, a wide variety of spectroscopies, mass spectrometry and bioinformatics. Finally, these core concepts will be used to explain the biochemical basis for enzyme function, protein synthesis, energy production in the cell and selected metabolic pathways.
Knowledge learned in lectures is re-enforced and augmented during six hours of laboratory work per week. Experiments will develop both your core practical skills (making buffers, taking measurements, analysing data) and introduce you to designing experiments to test hypotheses. Experiments include the separation and visualisation of protein mixtures, measurement and characterisation of enzyme catalysed reactions and quantifying serum cholesterol levels using a fluorescence assay.
Weekly small-group tutorials with your personal tutor will enhance your skills in numeracy, data handling and report writing. You will be asked to either write an essay on a specific topic or to answer a series of problems focussed on a recently taught topic. In addition to this formal interaction, this module provides you with an opportunity to discuss the subject and develop your scientific understanding with an expert in the field. You will also have the option to select optional modules and discovery modules from across the University.
At the end of year 1, our flexible degree structure offers you the opportunity to transfer onto other suitable degree courses.
We will introduce you to medical biochemistry-specific content, with the focus being an in-depth and increasingly research-led study of the major areas that underpin modern biochemistry taught by experts in each topic.
In lectures, you will be taught around the following three themes:
Genetic engineering – explains how the recent advances in DNA cloning together with methods to perturb gene expression complement the core methods of polymerase chain reaction (PCR) and restriction enzymes described in year 1. You will also learn how the proteins encoded by these synthetic genes are over-expressed and purified, so that their function and structure can be deduced.
Protein structure and function – continues to develop an understanding of how proteins work via lectures on their dynamics, folding and aggregation. You will also learn about analytical techniques such as Nuclear Magnetic Resonance (NMR), electron microscopy and mass spectrometry. Finally, you will be taught advanced enzyme kinetics and their catalytic mechanisms, rational and directed evolution protein engineering, and be introduced to the molecular mechanisms of chaperones, antibodies and antibiotics.
Biochemistry of health and disease – integrates these concepts to understand the structure, dynamics and function of organelles, cells and tissues. In addition you will learn cell biology techniques, basic innate and adaptive immunology and cellular control mechanisms and dysfunction including the cell cycle, gene regulation, genetic disease, cell signalling and cellular communication.
You will further develop your laboratory skills and take greater responsibility for your experimental design as you undertake a number of mini-projects. In level 2, your weekly six hours in the laboratory run in one day-long session, often over several weeks, allowing the integration of multiple approaches to answer a single question, reflecting the approach of modern research science.
Practicals include: cell biology project to analyse the effects of epidermal growth factors on the cell cycle, and drug discovery project where you will identify potential inhibitors of a therapeutic target protein by a computational method, testing the potency of selected inhibitors by using a high-throughput plate reader assay. These longer assignments run alongside more traditional biochemistry experiments such as determination the stoichiometry and specific activity of an enzyme.
Topics of tutorials used to secure your learning from the lecture and practical modules include organic reaction mechanisms, plant biology, strategies for gene cloning and protein expression, and investigating the molecular basis of phenylketonuria. Alongside this subject-specific knowledge, other tutorials start training in transferable skills required to compete successfully in the employment market. These include mock interviews, report writing and, with your personal tutor, the design and delivery of presentations. You will again have the option to select optional modules and discovery modules from across the University in year 2.
At the end of year 2 you will have the opportunity to complete an industrial work placement, study abroad, or combined study and work abroad. This will add an additional year of study to your degree.
Your lectures will be given as three advanced topic modules. Each module comprises of 6-8 topics covering molecular life sciences in its broadest sense. This enables students to study subjects most relevant to their interests and to their future careers. As advanced topics are given by research leaders the lecture content is research-led, often describing recent discoveries yet to appear in modern textbooks. These topics range from biophysics, biotechnology, mechanisms of disease and therapeutics, cell biology and modern biochemical methods. As a medical biochemist, you will be required to take one specialist topic per module, such as molecular oncology, innate immunity and protein folding and disease.
Your tutorial module will encompass tutorials, group work and presentations on critical analysis of scientific literature and scientific writing, attendance at School research seminars and problem sets and self-directed learning projects. The latter exercises are mock research projects based on model data that culminate in you analysing a real protein dataset obtained by nuclear magnetic resonance, mass spectrometry, electron microscopy or X-ray diffraction.
In the first semester, you will undertake an independent or group research project which further develops your analytical and communication skills. It will be a laboratory, literature or computer-based project, under the supervision of one of our expert research academics and will hypothesis-driven.
Recently offered laboratory projects with a medical focus include:
Replication of foot-and-mouth disease virus.
Ligand fragment screening for inhibitors ketohexokinases to combat obesity.
Transcriptomic and proteomic approaches to identify viral proteins that affect the host cell.
The molecular basis for antibiotic resistance in ‘superbugs’.
Recently offered literature projects with a medical focus include:
The pandemic spread of zoonotic viruses?
Aggregation and ageing: is disease inevitable and incurable?
Hedgehog signalling in colorectal cancer.
The specialisation and depth of your final year studies, together with your involvement in choosing the direction of your studies leaves you well placed to pursue your specialist interests and future career.
Integrated Masters (MBiol)
Our integrated masters MBiol programme shares the same year 1 and 2 studying with our BSc programme, providing a foundation knowledge and skills.
Year 3 (MBiol)
You will study the same advanced topics modules and skills module as BSc students. You will undertake advanced research practical training, which develops tailored biochemistry skills and provides the opportunity to become familiar with the cutting-edge research facilities available at Leeds. In year 3, you'll begin preparing for your extended research project which you take in year 4 by undertaking a literature review of the subject.
Year 4 (MBiol)
You’ll undertake an extended research project in one of the research laboratories under the supervision of one of our academics, alongside studying specialist research topics and a skills module which aims to prepare you for life as a professional scientist. As you are fully integrated into a group, you will contribute to internationally-competitive research which can result in CV-enhancing publications. Previous projects resulting in publications with a medical focus included using a nematode worm model to understand the molecular basis of Parkinson’s disease.
The list shown below represents typical modules/components studied and may change from time to time. Read more in our Terms and conditions.
For more information and a full list of typical modules available on this course, please read Medical Biochemistry MBiol, BSc in the course catalogue
For more information and a full list of typical modules available on this course, please read Medical Biochemistry BSc in the course catalogue
Introductory Biochemistry: Practical Skills
Introductory Biochemistry: Problem Solving and Data Handling
Introductory Integrated Biochemistry: the Molecules and Processes of Life
Introduction to Cell Biology: from Molecules to Cells and Tissues
Intermediate Biochemistry: Practicals
Intermediate Biochemistry: Skills
Biological Membranes and Cell Signalling
Cell Biology of Disease
Advanced Topics in Medical Biochemistry I
Advanced Topics in Medical Biochemistry 2
Advanced Topics in Medical Biochemistry 3
Advanced Biochemistry: Skills
Research Tools and Applications
Extended Research Project Preparation
Extended Research Project
Specialised Research Topics and Skills
Throughout your degree you will benefit from a range of opportunities to expand your intellectual horizons outside or within your subject area.
This course gives you the opportunity to choose from a range of discovery modules. They’re a great way to tailor your study around your interests or career aspirations and help you stand out from the crowd when you graduate. Find out more about discovery modules on our Broadening webpages.
Learning and teaching
You’ll experience a wide range of teaching methods including lectures, tutorials and practicals. Your first and second years will focus on these three teaching methods, building your skills, understanding and knowledge in preparation for your final year research project, which will see you take on independent research and learning with the guidance of leading experts.
Across all years, additional workshop and seminar sessions will complement your lectures and lab practicals, and you will also undertake private study.
As a guide, a typical week in your first year includes nine to twelve hours of lectures, three to six hours of practical sessions in the laboratory, tutorials, workshop and seminar sessions, plus private study.
Independent study and research are also crucial to every year of the course. We have excellent library and computing facilities to support your learning, and the University Library offers training to help you make the most of them.
On this course you’ll be taught by our expert academics, from lecturers through to professors. You may also be taught by industry professionals with years of experience, as well as trained postgraduate researchers, connecting you to some of the brightest minds on campus.
We use a variety of assessment methods to help you develop a broad range of skills. These include practical work, data handling and problem-solving exercises, multiple-choice tests, group work, online and face-to-face discussion groups, computer-based simulations, essays, posters and oral presentations.